Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells
نویسندگان
چکیده
منابع مشابه
Antigen recognition by cytotoxic T lympho-
| When cells are stimulated with pro-inflammatory cytokines, most of their constitutively expressed proteasomes are replaced with immunoproteasomes, which increase the production of peptides for presentation on MHC class I molecules. In addition, cortical thymic epithelial cells selectively express a type of proteasome known as the thymoproteasome that is required for the positive selection of ...
متن کاملAntigen Recognition by Cloned Cytotoxic T Lymphocytes
Antigen recognition by cytotoxic lymphocytes (CTL) 1 and by helper T cells is restricted by gene products of the major histocompatibility complex (MHC), called H-2 in the mouse (1). CTL recognize antigens in the context of Kand D-regionencoded structures, whereas helper T cells recognize antigen in the context of I-regionencoded structures. This H-2 restriction appears to be very tight: C T L s...
متن کاملRecognition of prostate tumor cells by cytotoxic T lymphocytes specific for prostate-specific membrane antigen.
The development of immunotherapy for cancer, such as synthetic peptide-based vaccines, relies heavily on the identification of appropriate epitopes capable of eliciting antitumor T-cell responses. We have used a combination of computer-based algorithms to predict peptide sequences from prostate-specific membrane antigen (PSMA) capable of stimulating in vitro CTLs restricted by the HLA-A2 MHC mo...
متن کاملTargeted delivery of adenoviral vectors by cytotoxic T cells.
Effective targeting of vectors to tumor cells that have metastasized to multiple different tissue sites remains a major challenge for gene therapy. Tumor-specific cytotoxic T lymphocytes (CTLs) have been shown in animal models and in humans to be able to cross tissue barriers and traffic to tumor cells. However, their capacity to eliminate malignancy has been limited by tumor immune evasion str...
متن کاملReceptor-Mediated Antigen Delivery by α2-Macroglobulin: Effect on Cytotoxic T Lymphocyte Immunity and Implications for Vaccine Development by
Receptor-Mediated Antigen Delivery by α2-Macroglobulin: Effect on Cytotoxic T Lymphocyte Immunity and Implications for Vaccine Development by Edith Villette Bowers Department of Pathology Duke University Date:_______________________ Approved: ___________________________ Salvatore V. Pizzo, MD, PhD, Supervisor ___________________________ George J. Cianciolo, PhD ___________________________ Soman...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomaterials
سال: 2017
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2016.11.048